Voriconazole: A second-generation triazole

P. H. Chandrasekar; E. Manavathu

doi:10.1358/dot.2001.37.2.614849

Voriconazole: A second-generation triazole

P. H. Chandrasekar, E. Manavathu

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Voriconazole, a derivative of fluconazole, is an antifungal triazole with expanded spectrum of activity against a variety of yeasts and filamentous fungi. It exhibits fungicidal activity against Aspergillus species. Preliminary data from animal models and clinical trials show promise in the treatment of candidiasis and aspergillosis. Of concern is the development of resistance to voriconazole and cross-resistance with other azoles. Voriconazole is a welcome addition to our limited armamentarium against potentially fatal fungal infections.

Original language	English (US)
Pages (from-to)	135-148
Number of pages	14
Journal	Drugs of Today
Volume	37
Issue number	2
DOIs	https://doi.org/10.1358/dot.2001.37.2.614849
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1358/dot.2001.37.2.614849

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AB - Voriconazole, a derivative of fluconazole, is an antifungal triazole with expanded spectrum of activity against a variety of yeasts and filamentous fungi. It exhibits fungicidal activity against Aspergillus species. Preliminary data from animal models and clinical trials show promise in the treatment of candidiasis and aspergillosis. Of concern is the development of resistance to voriconazole and cross-resistance with other azoles. Voriconazole is a welcome addition to our limited armamentarium against potentially fatal fungal infections.

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Voriconazole: A second-generation triazole

Abstract

ASJC Scopus subject areas

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