Wada memory and timing of stimulus presentation

We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset laterality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric aesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.