Wada memory and timing of stimulus presentation

D. W. Loring, K. J. Meador, G. P. Lee, M. E. Nichols, D. W. King, A. M. Murro, Y. D. Park, J. R. Smith

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset laterality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric aesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalEpilepsy Research
Issue number3
StatePublished - Feb 1997


  • Epilepsy surgery
  • Human epilepsy
  • Memory
  • Temporal lobectomy
  • Wada test

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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