Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M Murro; Don W. King; Joseph R. Smith; Brian B. Gallagher; Herman F. Flanigin; David W. Loring; Gregory P Lee; Rebecca Campbell; Kimford Meador; Patricia H. Revolinski

doi:10.1016/0896-6974(91)90121-X

Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M Murro, Don W. King, Joseph R. Smith, Brian B. Gallagher, Herman F. Flanigin, David W. Loring, Gregory P Lee, Rebecca Campbell, Kimford Meador, Patricia H. Revolinski

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original language	English (US)
Pages (from-to)	39-42
Number of pages	4
Journal	Journal of Epilepsy
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/0896-6974(91)90121-X
State	Published - Jan 1 1991

Keywords

Anticonvulsants
Complex partial seizures
Epilepsy
Epilepsy surgery
Temporal lobe epilepsy

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1016/0896-6974(91)90121-X

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title = "Withdrawal of antiepileptic medications following epilepsy surgery",

abstract = "We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.",

keywords = "Anticonvulsants, Complex partial seizures, Epilepsy, Epilepsy surgery, Temporal lobe epilepsy",

author = "Murro, {Anthony M} and King, {Don W.} and Smith, {Joseph R.} and Gallagher, {Brian B.} and Flanigin, {Herman F.} and Loring, {David W.} and Lee, {Gregory P} and Rebecca Campbell and Kimford Meador and Revolinski, {Patricia H.}",

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AU - Murro, Anthony M

AU - King, Don W.

AU - Smith, Joseph R.

AU - Gallagher, Brian B.

AU - Flanigin, Herman F.

AU - Loring, David W.

AU - Lee, Gregory P

AU - Campbell, Rebecca

AU - Meador, Kimford

AU - Revolinski, Patricia H.

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KW - Epilepsy surgery

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Withdrawal of antiepileptic medications following epilepsy surgery

Abstract

Keywords

ASJC Scopus subject areas

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