Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M. Murro; Don W. King; Joseph R. Smith; Brian B. Gallagher; Herman F. Flanigin; David W. Loring; Gregory P. Lee; Rebecca Campbell; Kimford Meador; Patricia H. Revolinski

doi:10.1016/0896-6974(91)90121-X

Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M. Murro, Don W. King, Joseph R. Smith, Brian B. Gallagher, Herman F. Flanigin, David W. Loring, Gregory P. Lee, Rebecca Campbell, Kimford Meador, Patricia H. Revolinski

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13 Scopus citations

Abstract

We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original language	English (US)
Pages (from-to)	39-42
Number of pages	4
Journal	Journal of Epilepsy
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/0896-6974(91)90121-X
State	Published - 1991

Keywords

Anticonvulsants
Complex partial seizures
Epilepsy
Epilepsy surgery
Temporal lobe epilepsy

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/0896-6974(91)90121-X

Cite this

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title = "Withdrawal of antiepileptic medications following epilepsy surgery",

abstract = "We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.",

keywords = "Anticonvulsants, Complex partial seizures, Epilepsy, Epilepsy surgery, Temporal lobe epilepsy",

author = "Murro, {Anthony M.} and King, {Don W.} and Smith, {Joseph R.} and Gallagher, {Brian B.} and Flanigin, {Herman F.} and Loring, {David W.} and Lee, {Gregory P.} and Rebecca Campbell and Kimford Meador and Revolinski, {Patricia H.}",

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T1 - Withdrawal of antiepileptic medications following epilepsy surgery

AU - Murro, Anthony M.

AU - King, Don W.

AU - Smith, Joseph R.

AU - Gallagher, Brian B.

AU - Flanigin, Herman F.

AU - Loring, David W.

AU - Lee, Gregory P.

AU - Campbell, Rebecca

AU - Meador, Kimford

AU - Revolinski, Patricia H.

PY - 1991

Y1 - 1991

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AB - We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

KW - Anticonvulsants

KW - Complex partial seizures

KW - Epilepsy

KW - Epilepsy surgery

KW - Temporal lobe epilepsy

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Withdrawal of antiepileptic medications following epilepsy surgery

Abstract

Keywords

ASJC Scopus subject areas

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