Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M. Murro; Don W. King; Joseph R. Smith; Brian B. Gallagher; Herman F. Flanigin; David W. Loring; Gregory P. Lee; Rebecca Campbell; Kimford Meador; Patricia H. Revolinski

doi:10.1016/0896-6974(91)90121-X

Withdrawal of antiepileptic medications following epilepsy surgery

Anthony M. Murro
, Don W. King
, Joseph R. Smith
, Brian B. Gallagher
, Herman F. Flanigin
, David W. Loring
, Gregory P. Lee
, Rebecca Campbell
, Kimford Meador
, Patricia H. Revolinski

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

Original language	English (US)
Pages (from-to)	39-42
Number of pages	4
Journal	Journal of Epilepsy
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/0896-6974(91)90121-X
State	Published - 1991

Keywords

Anticonvulsants
Complex partial seizures
Epilepsy
Epilepsy surgery
Temporal lobe epilepsy

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

Access to Document

10.1016/0896-6974(91)90121-X

Cite this

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title = "Withdrawal of antiepileptic medications following epilepsy surgery",

abstract = "We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77\% at 1 year, 72\% at 2 years, and 66\% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.",

keywords = "Anticonvulsants, Complex partial seizures, Epilepsy, Epilepsy surgery, Temporal lobe epilepsy",

author = "Murro, \{Anthony M.\} and King, \{Don W.\} and Smith, \{Joseph R.\} and Gallagher, \{Brian B.\} and Flanigin, \{Herman F.\} and Loring, \{David W.\} and Lee, \{Gregory P.\} and Rebecca Campbell and Kimford Meador and Revolinski, \{Patricia H.\}",

year = "1991",

doi = "10.1016/0896-6974(91)90121-X",

language = "English (US)",

volume = "4",

pages = "39--42",

journal = "Journal of Epilepsy",

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T1 - Withdrawal of antiepileptic medications following epilepsy surgery

AU - Murro, Anthony M.

AU - King, Don W.

AU - Smith, Joseph R.

AU - Gallagher, Brian B.

AU - Flanigin, Herman F.

AU - Loring, David W.

AU - Lee, Gregory P.

AU - Campbell, Rebecca

AU - Meador, Kimford

AU - Revolinski, Patricia H.

PY - 1991

Y1 - 1991

N2 - We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

AB - We followed 104 patients to determine the prognosis for antiepileptic medication withdrawal following anterior temporal lobectomy for complex partial seizures. Thirty-nine of the 104 patients underwent a trial of complete medication withdrawal following a minimum 1-year seizure-free postoperative period. The likelihood of remaining seizure-free in these 39 patients was 77% at 1 year, 72% at 2 years, and 66% at 3 years. A prolonged duration of epilepsy prior to surgery significantly increased the risk for recurrent seizures. These findings suggest that patients who remain seizure-free following surgery for temporal lobe complex partial seizures have a good prognosis for remaining seizure-free following anti-epileptic medication withdrawal.

KW - Anticonvulsants

KW - Complex partial seizures

KW - Epilepsy

KW - Epilepsy surgery

KW - Temporal lobe epilepsy

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Withdrawal of antiepileptic medications following epilepsy surgery

Abstract

Keywords

ASJC Scopus subject areas

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