Wound healing following surgical and regenerative periodontal therapy

Cristiano Susin, Tiago Fiorini, Jaebum Lee, Jamie A. De Stefano, Douglas P. Dickinson, Ulf M E Wikesjö

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Clinical studies have evaluated the effect of conventional periodontal surgical therapy. In general, although some clinical gain in tissue support may be attained, these therapies do not support regeneration of the periodontal attachment. Even though the biological possibility of periodontal regeneration has been demonstrated, the clinical application of this intrinsic potential appears difficult to harness; thus also conceptually most intriguing candidate protocols face clinical challenges. In this review, we explore the bioclinical principles, condiciones sine quibus non, that unleash the innate potential of the periodontium to achieve clinically meaningful periodontal regeneration (i.e. space-provision, wound stability and conditions for primary intention healing). Moreover, limiting factors and detrimental practices that may compromise clinical and biological outcomes are reviewed, as is tissue management in clinical settings.

Original languageEnglish (US)
Pages (from-to)83-98
Number of pages16
JournalPeriodontology 2000
Issue number1
StatePublished - Jun 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Periodontics


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