Zoledronate and ion-releasing resins impair dentin collagen degradation

A. Tezvergil-Mutluay, R. Seseogullari-Dirihan, V. P. Feitosa, F. R. Tay, T. F. Watson, D. H. Pashley, S. Sauro

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


This study analyzed the amounts of solubilized telopeptides cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and C-terminal crosslinked telopeptide of type I collagen (CTX) derived from matrix-metalloproteinases (MMPs) and cysteine cathepsins (CTPs) subsequent to application of a filler-free (Res.A) or an ion-releasing resin (Res.B) to ethylenediaminetetraacetic acid (EDTA)-demineralized dentin with or without zoledronate-containing primer (Zol-primer) pre-treatment. The chemical modification induced following treatments and artificial saliva (AS) storage was also analyzed through attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Totally EDTA-demineralized specimens were infiltrated with Res.A or Res.B with or without Zol-primer pre-treatment, light-cured, and immersed in AS for up to 4 wk. ICTP release was reduced following infiltration with Res.B and further reduced when Res.B was used with Zol-primer; remarkable phosphate mineral uptake was attained after AS storage. CTX release was increased in Res.A- and Res.B-treated dentin. However, when Zol-primer was used with Res.A, the CTX release fell significantly compared to the other tested resin-infiltration methods. In conclusion, zoledronate offers an additional inhibitory effect to the ion-releasing resins in MMP-mediated collagen degradation. However, Zol-primer induces a modest reduction in CTX release only when used with resin-based systems containing no ion-releasing fillers.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalJournal of Dental Research
Issue number10
StatePublished - Oct 1 2014


  • bisphosphonates
  • calcium phosphates
  • cathepsins
  • matrix metalloproteinase
  • phosphorylation
  • proteolysis

ASJC Scopus subject areas

  • General Dentistry


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