GENERAL CLINICAL RESEARCH CENTER

The purpose of this research center is to provide facilities for the
conduct of clinical research at the Tufts-New England Medical Center
Hospital. The Unit serves the research requirements of the entire medical
center and is capable of providing a wide base of support for a variety of
clinical studies. The major studies now underway are: epidemiology and
biology of medullary thyroid carcinoma; mechanisms and therapy of endocrine
disorders including Cushing's disease, acromegaly, secondary amenorrhea,
sexual dysphoria, galactorrhea/amenorrhea/hyperprolactinemic syndromes,
diabetes mellitus and insipidus, multinodular goiter, and
panhypopituitarism; investigations in metabolic neuromuscular diseases
including tardive dyskinesia, Friedreich's ataxia, peroneal muscular
atrophy, amytrophic lateral sclerosis and the apinal muscular atrophies,
Parkinson's disease and other degenerative neurological conditions; therapy
of primary biliary cirrhosis with penicillamine and vitamin D.
Investigations of immune complex diseases; gonadotropin and growth hormone
short loop feedback; role of endorphins in growth hormone regulation;
ecology of debilitated E. Coli; mechanisms of diarrhea; glucose kinetics in
sepsis; studies of the serum amyloid protein; high dose cyclophosphamide
treatment of osteogenic and Ewing's sarcoma; study of hirsute and virilized
females; effect of choline and lecithin administration on memory function
in man; anti-hypertensive drugs and growth hormone secretion;prolactin
secretion in "euprolactinemic" galactorrhea with abnormal pituitary fossa
x-rays; luteinizing hormone-releasing hormone metabolism-role of the
n-terminal, hexapeptide as in index of LH-RH secretion; neuropsychiatric
aspects of pituitary prolactinomas; etiology of amyotrophic lateral
sclerosis; ulcerative colitis and cancer; precise localization of seizure
discharge foci utilizing chronic cortical EEG; acquired factor x deficiency
and systemic amyloidosis; effect of body habitus, age, nutritional status
on acetaminophen kinetics; temazepam kinetics in young and old humans;
pharmacokinetics of intravenous, intramuscular, oral, sublingual lorazepam;
clorazepam kinetics in young and elderly humans.