GENETIC ANALYSIS OF NEUROBLASTOMA
- ,
- JOHN K. COWELL(PI),
- JOHN COWELL(PI)
- ,
- ROSWELL PARK CANCER INSTITUTE CORP,
- Cleveland Clinic Foundation
Grant:
Research project
Project status
Finished
About the Project
DESCRIPTION: Neuroblastoma (NB) is the most common solid tumor in children
and accounts for 15% of all childhood cancer deaths. Inheritance has been
implicated in NB although the location of predisposing gene(s) has not been
identified. Constitutional translocations have been valuable tools for gene
discovery in a large number of human diseases, where it has been shown
repeatedly that the interrupted gene is responsible for the disease. The PI
has identified 2 NB subjects with constitutional translocations. The goal
of the proposed work is to characterize the breakpoints and identify the
genes disrupted by the translocations.
Project Information
Project Type
Research project