PROJECT 2 - Kyn-AhR interactions modulating muscle-bone crosstalk with aging

Muscle and bone loss with age are underlying factors contributing to falls and fractures in the elderly. These fractures are very costly both in terms of financial burden and quality of life. This project will determine whether inhibitors of the kynurenine pathway, a key pathway involved in aging, can improve muscle and bone function with aging as a strategy to prevent falls and fractures.