Sex difference in cognitive impairment in a novel humanized AD model

According to the 2023 Alzheimer's Association Facts & Figures report, of the more than 6.5 million Americans with Alzheimer's, nearly two-thirds are women. However, the reasons underlying these sex differences in Alzheimer's remain unclear. Some research suggests that chronic sleep deprivation, as well as sex hormone changes that occur during pregnancy and menopause, may impact cognition and the development of Alzheimer's in women. However, the mechanisms by which these factors are linked to Alzheimer's are unknown. For their studies, Dr. Ferenc Deak and colleagues have developed new genetically engineered Alzheimer's-like mice to study the mechanisms linking sleep deprivation and sex hormone changes to Alzheimer's development in women.