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4. The age dependencies of MRI abnormalities in schizophrenia suggest early ventricular enlargement but later prominence of cortical atrophy

  • John L. Waddington(corresponding author)
    ,
  • Eadbhard O'Callaghan
    ,
  • Peter Buckley
    ,
  • Conall Larkin
    ,
  • Oonagh Redmond
    ,
  • John Stack
*Corresponding author for this work
  • Royal College of Surgeons in Ireland
    ,
  • Mid-Western Regional Hospital Limerick
    ,
  • Mater Hospital
Scholary Output:
Contribution to journal
Article
 Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 188-189 (2 pages)

Journal (Volume, Issue Number)

Schizophrenia Research (Volume 5, Issue 3)

Publication milestones

  • Published - 10/1991

Publication status

Published - 10/1991

ISSN

0920-9964

Publication IDs

  • Scopus: 0026091823
  • PubMed: 1760387

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Funding Details

Individuals. In this regard. it is noteworthy that structural abnormalities have not been confined to the anterior cingulate cortex in schizophrenia. For example, disturbances in layer II of the prefrontal (Benes et al.. 1991) and entorhinal cortex (Jakoh and Beckman. 1986: Falkai et al., 198X) in schizophrenics have also been reported and a disturbance of early brain ontogeny has been similarly proposed for the entorhmal region (Jakoh and Beckmann, 1986). Thus. studies in independent lahoraiories have yielded data in support of a neurodevelop-mental model of schizophrenia in which pcrinatal complications play a role (Weinherger. 1987; Benes. 1989). To obtain further support for such an hypothesis, it wjill he necessary to determine whether individuals without schizophrenia who were also exposed to obstetrical complications might also show alterations in the structure of cortical layer II. Moreover. since it is unlikely that perinatal insults alone can explain the occurrence of schizophrenia in ccrtaln individuals. it will he important to determine whether there are additional structural changes that may he associated with other risk factors for schizophrenia. such as an abnormal gene. To do this. It will he necessary to develop strntcgics for determining whether other microscopic differences in schizophrenic brain. such as excess numbers of associative connections in anterior cingulate cortex (Benes et al.. 1987). not explainable by a perinatal injury. may hc related to an inhcrlted trait. In this way, it may eventually he possible to derive a two-factor model of schizophrenia expressed in terms of discrete alterations in brain circuitry. Ac~hno~c~/edgcr?~c~nt.Ss.u pported by grants from the NatIonal Institute of Mental Health MHOO423 and MH42261, and a grant from the Scottish Rite Foundation for Schizophrenia Research. iic,Xrlol~./~,cl~c,r?T~hcisn /w. sork was supported by the St. John of God Order.