A new class of cardiotonic steroids
Original title: Novyǐ klass kardiotonicheskikh steroidov.
- A. V. Kamernitskiǐ(corresponding author),
- I. A. Kutnevich,
- I. G. Reshetova,
- E. I. Chernoburova,
- B. A. Gorshkov,
- I. A. Gorshkova
- Unknown
Scholary Output:
Contribution to journal
Letter
Peer-reviewAbstract
A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.
Publication Information
Output type
Scholary Output:
Contribution to journal
Letter
Peer-reviewOriginal language
RussianPages from-to (Number of pages)
Pages 141-143 (3 pages)Journal (Volume, Issue Number)
Bioorganicheskaia khimiia (Volume 17, Issue 1)Publication milestones
- Published - 01/1991
Publication status
Published - 01/1991
ISSN
0132-3423Publication IDs
- Scopus: 17044447655
- PubMed: 1648353
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