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Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

  • N. A. Lambert(corresponding author)
    ,
  • N. L. Harrison
    ,
  • D. I.B. Kerr
    ,
  • J. Ong
    ,
  • R. H. Prager
    ,
  • T. J. Teyler
*Corresponding author for this work
  • Northeastern Ohio Universities College of Medicine
    ,
  • The University of Chicago
    ,
  • University of Adelaide
    ,
  • Flinders University
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potentials from CA1 hippocampal neurons. 2-Hydroxy-saclofen (50-200 μM) reversibly blocked the late, GABAB receptor-mediated inhibitory postsynaptic potential (IPSP) but not the early, GABAA receptor-mediated IPSP. In addition, the hyperpolarizing response to baclofen was reduced by similar concentrations of 2-hydroxy-saclofen. This suggests that 2-hydroxy-saclofen is a potent antagonist at postsynaptic GABAB receptors on hippocampal neurons.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 125-128 (4 pages)

Journal (Volume, Issue Number)

Neuroscience Letters (Volume 107, Issue 1-3)

Publication milestones

  • Published - 12/15/1989

Publication status

Published - 12/15/1989

ISSN

0304-3940

Publication IDs

  • Scopus: 0024971971
  • PubMed: 2559366

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