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Cardiovascular Toxicity of Novel HER2-Targeted Therapies in the Treatment of Breast Cancer

  • Susan F. Dent
    ,
  • Amber Morse
    ,
  • Sarah Burnette
    ,
  • Avirup Guha
    ,
  • Heather Moore
Scholary Output:
Contribution to journal
Article
 Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Purpose of Review: HER2-targeted therapies have led to improved clinical outcomes in early and advanced breast cancer (BC). We review the long-term cardiotoxicity of HER2-targeted therapy in early and advanced BC, our current knowledge of cardiotoxicity of novel HER2-targeted therapies, and propose a cardiac monitoring (CM) strategy for this population. Recent Findings: Long-term data from studies with HER2-targeted therapy in the adjuvant setting have failed to demonstrate an increase in cardiotoxicity over time, and rates of cardiotoxicity seen with novel HER2 agents remain low. Despite over a decade of experience with HER2-targeted therapy, CM in clinical practice is inconsistent in patients with early BC and almost non-existent in advanced BC. Summary: Long-term follow-up of clinical trials with HER2-targeted agents in early and advanced BC has failed to demonstrate increased rates of cardiotoxicity over time, attesting to the long-term safety of this class of drugs for the majority of patients, although the long-term cardiac safety of newer HER2 agents in the non-clinical trial setting is largely unknown. We propose CM incorporating clinical history, cardiac imaging, and biomarkers.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Journal (Volume, Issue Number)

Current Oncology Reports (Volume 23, Issue 11)

Publication milestones

  • Published - 11/01/2021

Publication status

Published - 11/01/2021

ISSN

1523-3790

Publication IDs

  • PubMed: 34453232
  • Scopus: 85113680038
  • ORCID: /0000-0003-0253-1174/work/110363158

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