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Characterization of muscarinic acetylcholine receptors in human labial salivary glands

  • Lin Mei
    ,
  • William R. Roeske
    ,
  • Kenneth T. Izutsu
    ,
  • Henry I. Yamamura(corresponding author)
*Corresponding author for this work
  • Unknown
    ,
  • University of Washington
    ,
  • University of Arizona
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

Muscarinic acetylcholine receptors were studied in human labial salivary glands with (-)-[3H]MQNB. The radioligand bound with a Kd value of 150 pM. The density of muscarinic receptors was 220 fmol/mg protein. Most muscarinic antagonists bound to a homogenous population of muscarinic receptors in this tissue. However, the inhibition curves of pirenzepine had a Hill slope of 0.57 and could be analyzed by a two site model. These results suggest that the muscarinic receptors in human labial salivary glands are a mixture of M1 and M3 types.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 367-370 (4 pages)

Journal (Volume, Issue Number)

European Journal of Pharmacology (Volume 176, Issue 3)

Publication milestones

  • Published - 02/13/1990

Publication status

Published - 02/13/1990

ISSN

0014-2999

Publication IDs

  • Scopus: 0025137526
  • PubMed: 2328757

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Funding Details

This work was supported in part by U.S. Public Health Service Grants HL-20984, DK-36289 and DK-35975. The authors would like to thank Ms. Pam Davis for secretarial services.
FundersFunding numbers
NIDDK
R01DK035975
USPHS
HL-20984, DK-36289