Compounds of IL-6 Receptor Complex during Acute Lung Injury
- D. A. Chepurnova(corresponding author),
- E. V. Samoilova,
- A. A. Anisimov,
- ,
- A. A. Korotaeva
- Russian Ministry of Health,
Scholary Output:
Contribution to journal
Article
Peer-review
Open access
Abstract
Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 609-611 (3 pages)Journal (Volume, Issue Number)
Bulletin of Experimental Biology and Medicine (Volume 164, Issue 5)Publication milestones
- Published - 03/01/2018
Publication status
Published - 03/01/2018
ISSN
0007-4888Publication IDs
- Scopus: 85044360811
- PubMed: 29577202
Publication metrics
Metrics
SciVal
citations
6
Fractional count
1
Fractional count
0.20
Fractional count
4
Fractional count
0.80
Fractional count
1
Fractional count
1
SciVal
FWCI
0.44
SciVal
Author count
5
SciVal
Paper percentile
70
PlumX, opens in new tab
Citation count
22
Captures
8
Funding Details
The experiments were supported by the National Institute of Health, USA (grant HL101902) and Russian Foundation of Basic Research (grant No. 16-04-00410).
FundersFunding numbers
Russian Foundation for Basic Research
16-04-00410
Foundation for the National Institutes of Health
-NHLBI
P01HL101902