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Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin

*Corresponding author for this work
  • University of Alabama at Birmingham
    ,
  • National Institute for Viral Disease Control and Prevention
Scholary Output:
Contribution to journal
Article
 Peer-review

Open access

Abstract

Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α2ARs accelerates α2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α2AAR endocytosis via PKA-dependent disruption of α2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 29193-29205 (13 pages)

Journal (Volume, Issue Number)

Journal of Biological Chemistry (Volume 288, Issue 40)

Publication milestones

  • Published - 10/04/2013

Publication status

Published - 10/04/2013

ISSN

0021-9258

Publication IDs

  • Scopus: 84885143688
  • PubMed: 23965992

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Fractional count
2
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2
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0.50
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2
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1

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Citation count
10
Captures
12

Funding Details

FundersFunding numbers
National Institutes of Health, National Cancer Institute
MH081917
NIMH
R01MH081917