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Discordance in deoxyribonucleic acid analysis of fetus and trophoblast

  • William J. Butler(corresponding author)
    ,
  • Charles E. Schwartz
    ,
  • Suzanne M. Sauer
    ,
  • John T. Wilson
    ,
  • Paul G McDonough
*Corresponding author for this work
  • Department of Obstetrics and Gynecology
    ,
  • Greenwood Genetics Center
    ,
  • Medical College of Georgia
    ,
  • Physiology
Scholary Output:
Contribution to journal
Article
 Peer-review

Open access

Abstract

Molecular analysis of deoxyribonucleic acid extracted from trophoblast has become an important component of modern prenatal diagnosis. Discrepancies between trophoblast and fetal tissue in both chromosomal and metabolic analysis have been reported. We studied 50 paired fetal and trophoblast deoxyribonucleic acid specimens with a highly polymorphic probe for repetitive "minisatellite" regions of deoxyribonucleic acid that may be areas of high recombination. Four pairs showed persistent variations in bands consistent with differences in fetal and trophoblast deoxyribonucleic acid. Discordance in trophoblast deoxyribonucleic acid as a reflection of fetal genotype may be secondary to mitotic recombination or sister chromatid exchange in the trophoblast, and the possiility of discordance must be considered in interpreting the results of prenatal diagnostic testing on trophoblast specimens.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 642-645 (4 pages)

Journal (Volume, Issue Number)

American journal of obstetrics and gynecology (Volume 158, Issue 3 PART 1)

Publication milestones

  • Published - 03/1988

Publication status

Published - 03/1988

ISSN

0002-9378

Publication IDs

  • Scopus: 0023856151
  • PubMed: 2831721

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Citation count
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Funding Details

From the Section of Reproductive Endocrinology, Infertility and Ge-netirs, Department of Obstetrics and G_vnecology" and the Depart-ment of Oral Biology, School of Dentistry, Medical College of Geor-gia, and the Recombinant DNA Laboratory, Greenwood Genetics Center. · This work was supported in part by grant1 from the Self Foundation and the South Carolina Department of Mental Retardation. Received for publication August JO, 1987; revised September JO, 1987; accepted October 19, 1987. Reprint requests: William]. Butler, MD, Director, Reproductive En-docrinology and Reproductive Genetics, Department of Obstetrics and Gynecology, Albany Medical College, Albany, NY 12208.