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Early-onset respiratory failure caused by severe congenital neuromuscular disease

  • D. L. Sandler
    ,
  • D. J. Burchfield
    ,
  • J. A. McCarthy
    ,
  • A. M. Rojiani
    ,
  • W. H. Drummond(corresponding author)
*Corresponding author for this work
  • University of Florida
    ,
  • Johns Hopkins University
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

Two unrelated infants with low Apgar scores, pneumothoraces, and severe pulmonary hypertension were treated with extracorporeal membrane oxygenation while receiving chemical sedation and neuromuscular paralysis. After decannulation from extracorporeal membrane oxygenation, hypotonia and hypoventilation persisted. Neurologic evaluation confirmed that both infants had a congenital myopathy.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 636-638 (3 pages)

Journal (Volume, Issue Number)

The Journal of Pediatrics (Volume 124, Issue 4)

Publication milestones

  • Published - 04/1994

Publication status

Published - 04/1994

ISSN

0022-3476

Publication IDs

  • Scopus: 0028297733
  • PubMed: 8151483

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0.80
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1
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1

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Citation count
14
Captures
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Funding Details

The infant arrived with hypotonia and minimal spontaneous activity, receiving fentanyl and pancuronium. A radiograph of the Supported in part by grants 92CG1A/7 and 92GIA/858 from the American Heart Association, Florida Affiliate. Submitted for publication Sept. 28, 1993; accepted Dec. 29, 1993. Reprint requests: W. H. Drummond, MD, Department of Pediatrics, Box 100296 JHMHC, Gainesville, FL 32610. Copyright | 1994 by Mosby-Year Book, Inc. 0022-3476/94/$3.00 + 0 9/24/53900 chest showed resolving pneumothoraces, clear lung fields, and thin ribs (Fig. 1, A). When the infant's respiratory failure worsened, he was treated with ECMO for 6 days without complications. Hypotonia persisted after discontinuation of sedation. At age 12 days, extubation failed because of atelectasis and hypoventilation. Computed tomography of the head showed mild cerebral atrophy, and focal slowing was present on an electroencephalogram.