Effect of inoculum size on the induction of endophthalmitis in aphakic rabbit eyes
- Robert K. Shockley,
- Walter M. Jay(corresponding author),
- Peggy H. Fishman,
- Mervat Z. Aziz,
- J. Peter Rissing
- Administration Medical Center,
- Medical College of Georgia,
Abstract
Abstract. A reproducible animal model is necessary to examine the use of antimicrobial agents for prophylaxis and treatment of bacterial endophthalmitis. We determined the minimum inoculum size of S. aureus and P. aeruginosa that consistently produced endophthalmitis when injected into aphakic rabbit eyes immediately following surgery. Both anterior chamber and intravitreal injections were examined. For S. aureus, an intravitreal inoculum of 19.3 ± 7.5 CFU and an anterior chamber inoculum of 50.5 ± 4.0 CFU were required. For P. aeruginosa, an intravitreal inoculum of 5.5 ± 2.6 CFU and an anterior chamber inoculum of 97.5 ± 10.7 CFU consistently produced a fulminant infection. Lower inocula of both bacteria produced endophthalmitis in both locations, but the effect was inconsistent. 1985 Institution Acta Ophthalmologica Scandinavica
Publication Information
Output type
Original language
English (US)Pages from-to (Number of pages)
Pages 35-38 (4 pages)Journal (Volume, Issue Number)
Acta Ophthalmologica (Volume 63, Issue 1)Publication milestones
- Published - 02/1985
Publication status
ISSN
1755-375XPublication IDs
- Scopus: 0021961993
- PubMed: 3873166