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Extreme shear rate dependence of leukocyte rolling in CD18-/-E-selectin/-double mutant mice

  • Brad Forlow(corresponding author)
    ,
  • Dan Bullard
    ,
  • Arthur Beaudet
    ,
  • Klaus Ley
*Corresponding author for this work
Scholary Output:
Contribution to journal
Conference article
 Peer-review

Related Event

Title

2000 Annual Fall Meeting of the Biomedical Engineering Society

Event type

Other

Date

10/12/2000 - 10/14/2000

Location

Washington, WA, USA

Abstract

A study was carried out to examine the impact of shear rate on slow leukocyte rolling and subsequent adhesion in C57BL/6 mice lacking CD18 integrins (CD18-/-), and/or E-selectin (CD62E-/-) using a TNFα-induced model of inflammation of the mouse cremaster muscle. In general, the combined deficiency of CD18 and E-selectin produced the most severe reduction of neutrophil recruitment in any mouse model described so far.

Publication Information

Output type

Scholary Output:
Contribution to journal
Conference article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages S-91

Journal (Volume, Issue Number)

Annals of Biomedical Engineering (Volume 28, Issue SUPPL. 1)

Publication milestones

  • Published - 2000

Publication status

Published - 2000

ISSN

0090-6964

Publication IDs

  • Scopus: 0034510958

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