Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans
- Donovan Thomas,
- Katherine Klein,
- Elias Manavathu,
- Jonathan R. Dimmock,
- Bulent Mutus(corresponding author)
- University of Windsor,
- Wayne State University,
- University of Saskatchewan
Scholary Output:
Contribution to journal
Article
Peer-reviewAbstract
Glutathione (GSH) levels were directly monitored by reverse phase HPLC during the thermal yeast-to-mycelial induction of Candida albicans. The GSH levels decreased ∼ 100-fold within 120 min which corresponded to the time of maximal yeast-to-mold conversion. The yeast to mold conversion was inhibited by 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one (CDDP) [1], a thiol-specific alkylator, which prevented the decline in GSH levels. These results are discussed with respect to the potential involvement of intracellular GSH levels in regulation of the yeast-to-mold dimorphism in Candida albicans.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 331-334 (4 pages)Journal (Volume, Issue Number)
FEMS Microbiology Letters (Volume 77, Issue 2-3)Publication milestones
- Published - 01/15/1991
Publication status
Published - 01/15/1991
ISSN
0378-1097Publication IDs
- Scopus: 0026424280
- PubMed: 2037237
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1
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0.80
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Funding Details
This researchw as supportedb y grants from National Science and EngineeringR esearch Council of Canada.K .K. receiveda n Employment and ImmigrationC anadaS ummerE mployment/ ExperienceD evelopmenPt rogrammeg rant.The authors would like to thank Mr. C. Hogue for developingth e HPLC methodology.
FunderFunding numbers
National Science and EngineeringR esearch Council of Canada.K
-