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HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

  • Chloé Loiseau
    ,
  • Daniela Brites
    ,
  • Miriam Reinhard
    ,
  • Kathrin Zürcher
    ,
  • Sonia Borrell
    ,
  • Marie Ballif
*Corresponding author for this work
  • Swiss Tropical and Public Health Institute
    ,
  • University of Basel
    ,
  • University of Bern
    ,
  • University of Cape Town
    ,
  • Ifakara Health Institute
    ,
  • Imperial College London
Scholary Output:
Contribution to journal
Article
Research
 Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
Research
 Peer-review

Original language

English (US)

Article number

e00782

Journal (Volume, Issue Number)

Antimicrobial agents and chemotherapy (Volume 64, Issue 10)

Publication milestones

  • Published - 10/2020

Publication status

Published - 10/2020

ISSN

0066-4804

Publication IDs

  • Scopus: 85091470049
  • PubMed: 32718966

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Funding Details

Asia-Pacific, U01AI069907; CCASAnet, U01AI069923; Central Africa, U01AI096299; East Africa, U01AI069911; NA-ACCORD, U01AI069918; Southern Africa, U01AI069924; and West Africa, U01AI069919. Informatics resources are supported by the Harmonist Project, R24AI124872. This work is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. R.J.W. is supported by the Francis Crick Institute, which receives funding from Wellcome (FC0010218), CRUK (FC0010218), and UKR1 (FC0010218). He is also supported by Wellcome (104803 and 203135). This research was supported by the Swiss National Science Foundation (grant numbers 153442, 310030_188888, 174281, and IZRJZ3_164171). The International Epidemiology Databases to Evaluate AIDS (IeDEA) is supported by the U.S. National Institutes of Health’s National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Cancer Institute, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Heart, Lung, and Blood Institute, the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Diabetes and Digestive and Kidney Diseases, the Fogarty International Center, and the National Library of Medicine:
FundersFunding numbers
UKR1
-
NICHD
-
NIDDK
-
NIMH
-
FCI
-
NIH
-
NIAID
-
CRUK
-
NCI
-
NIDA
-
FIC
-
NHLBI
-
NLM
-
NIAAA
-
SNF
174281, 310030_188888, 164171, 153442, 188888, IZRJZ3_164171
WT
203135, FC0010218, 104803
Harmonist Project
R24AI124872