IgE antibody in the serum - Detection and diagnostic significance

Technology for detection and measurement of allergen-specific IgE has helped bring the field of allergy into the modern era of medicine. This review has attempted to summarize technical and scientific issues in specific IgE immunoassay in a manner that is directly relevant to the care of patients. Challenges facing this technology include improving quality of the source materials used for testing, the rational incorporation of recombinant allergens in diagnostic testing, the universal reporting of quantitative results, and critical evaluation of the clinical significance of both low and high specific IgE levels.