In vitro evidence for the protective role of sida rhomboidea. Roxb extract against LDL oxidation and oxidized ldl-induced apoptosis in human monocyte-derived macrophages
- Menaka C. Thounaojam,
- Ravirajsinh N. Jadeja,
- Ranjisinh V. Devkar,
- A. V. Ramachandran
- M.S. University of Baroda
Abstract
The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.
Publication Information
Output type
Original language
English (US)Pages from-to (Number of pages)
Pages 168-179 (12 pages)Journal (Volume, Issue Number)
Cardiovascular Toxicology (Volume 11, Issue 2)Publication milestones
- Published - 06/2011
Publication status
ISSN
1530-7905Publication IDs
- Scopus: 79958040996
- PubMed: 21384160