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Isolation and characterization of a novel disialoganglioside from bovine adrenal medulla

  • Toshio Ariga(corresponding author)
    ,
  • Michiko Sekine
    ,
  • Robert K. Yu
    ,
  • Tadashi Miyatake
*Corresponding author for this work
  • Tokyo Metropolitan Institute of Medical Science
    ,
  • Yale University
    ,
  • Niigata University
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

A novel GDlb ganglioside which contains only N-glycolylneuraminic acid was isolated from bovine adrenal medulla by DEAE-Sephadex A-25 and Iatrobeads column chromatography. The concentration of this ganglioside was 0.9 nmol lipid-bound sialic acid per gram fresh tissue, which accounted for 2.7% of the disialoganglioside fraction. The structure was elucidated by sugar analysis, neuraminidase digestion, and permethylation studies. The complete structure of this ganglioside was identified as GDlb (NeuGc)2 or II3 (NeuGc)2-GgOse4Cer.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 305-309 (5 pages)

Journal (Volume, Issue Number)

Archives of Biochemistry and Biophysics (Volume 232, Issue 1)

Publication milestones

  • Published - 07/1984

Publication status

Published - 07/1984

ISSN

0003-9861

Publication IDs

  • Scopus: 0021202602
  • PubMed: 6547584

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Funding Details

This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science, and Culture of Japan. R.K.Y. was supported by USPHS Grant NS 11853 and NMSS Grant RG 1289-B-3. We thank Ms. Debbie Tewksbury for careful and prompt word processing.
FundersFunding numbers
NINDS
R01NS011853
NMSS
RG 1289-B-3
USPHS
-
MEXT
-