L-selectin in inflammation, infection and immunity

L-selectin (CD62L) is an adhesion molecule expressed on most leukocytes. This article describes recent findings of L-selectin's role in the recruitment of T cells to sites of inflammation and its contribution to the acquisition of immunologic memory. We discuss the regulation of L-selectin expression during and after the activation of T cells and its physiological function during the course of inflammation. Different disease models and current approaches for drug development are reviewed.