Mimicking a proline tripeptide with pyrazolidines and a cyclopentane linker
- Peter Vertesaljai,
- Iryna O. Lebedyeva,
- Alexander A. Oliferenko,
- Xin Qi,
- Junjie Fu,
- David A. Ostrov
- University of Florida,
- EigenChem Technologies Inc.,
- King Abdulaziz University
Scholary Output:
Contribution to journal
Article
Peer-reviewAbstract
In this work the five-step assembly of a peptidomimetic structurally resembling Prolyl-Prolyl-Proline tripeptide is reported. Proline units are mimicked by two pyrazolidine rings connected to trans-1,2-cyclopentanedicarboxylic acid. The Pro-Pro-Pro mimetic resembles a tri-l-proline unit but with increased lipophilicity and structural constraints imposed by the linker.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 6653-6655 (3 pages)Journal (Volume, Issue Number)
Tetrahedron Letters (Volume 56, Issue 48)Publication milestones
- Published - 07/13/2015
Publication status
Published - 07/13/2015
ISSN
0040-4039Publication IDs
- Scopus: 84955214233
Publication metrics
Metrics
Fractional count
1
Fractional count
0.11
Fractional count
8
Fractional count
0.89
Fractional count
1
Fractional count
1
SciVal
FWCI
0.11
SciVal
Author count
9
SciVal
citations
1
SciVal
Paper percentile
33
PlumX, opens in new tab
Social media
7
Captures
11
Citation count
2
Funding Details
We thank the University of Florida and the Kenan Foundation for support with this project. This Letter was also funded in part by generous support from King Abdulaziz University – Saudi Arabia, under grant N o D-006/431 . The authors, therefore, acknowledge the technical and financial support of KAU . The authors are grateful to Mr. Z. Wang for helpful discussion and Dr. M.C.A. Dancel (University of Florida) for HRMS analyses.
FundersFunding number
Kenan Foundation
-UF
-KAU
N o D-006/431