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MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

  • W. Y. Lam
    ,
  • Ariel C.Y. Cheung
    ,
  • Christine K.C. Tung
    ,
  • Apple C.M. Yeung
    ,
  • Karry L.K. Ngai
    ,
  • Vivian W.Y. Lui
*Corresponding author for this work
  • Chinese University of Hong Kong
    ,
  • The University of Hong Kong
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 246-254 (9 pages)

Journal (Volume, Issue Number)

FEBS Letters (Volume 589, Issue 2)

Publication milestones

  • Published - 01/16/2015

Publication status

Published - 01/16/2015

ISSN

0014-5793

Publication IDs

  • Scopus: 84920747667
  • PubMed: 25497012

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Funding Details

We acknowledge support from the Research Fund for the Control of Infectious Diseases, Food and Health Bureau, Hong Kong Special Administrative Region (Reference No.:11100112). The authors thank Miss. Bella Lam and Prof. S.S.C. Chim of the Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong for their generous support and assistance on the project.
FunderFunding numbers
Research Fund for the Control of Infectious Diseases, Food and Health Bureau
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