Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target
- Chengyuan Tang,
- Juan Cai,
- Zheng Dong(corresponding author)
- Central South University,
Scholary Output:
Contribution to journal
Comment/debate
Peer-review
Open access
Sustainable Development Goals
SDG 3 Good Health and Well
Abstract
Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet–induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease.
Publication Information
Output type
Scholary Output:
Contribution to journal
Comment/debate
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 930-933 (4 pages)Journal (Volume, Issue Number)
Kidney International (Volume 90, Issue 5)Publication milestones
- Published - 11/01/2016
Publication status
Published - 11/01/2016
ISSN
0085-2538Publication IDs
- Scopus: 84994176237
- PubMed: 27742195
Publication metrics
Metrics
Fractional count
1
Fractional count
0.33
Fractional count
2
Fractional count
0.67
Fractional count
1
Fractional count
1
SciVal
FWCI
2.11
SciVal
Author count
3
SciVal
citations
13
SciVal
Paper percentile
77
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Captures
37
Citation count
30
Funding Details
The work of the authors was supported in part by grants from National Natural Science Foundation of China [81430017, 81370791], the National Institutes of Health, and the US Department of Veteran Affairs.
FundersFunding numbers
NIH
-NIDDK
R01DK087843
VA
-NSFC
81370791, 81430017