Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer
- Leslie Duncan,
- Chloe Shay,
- Yong Teng(corresponding author)
- Augusta University,
- Emory University,
Open access
Sustainable Development Goals
SDG 3 Good Health and Well
Abstract
The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological processes as they can function as transcription regulators, decoys, scaffolds, and enhancer RNAs. Currently, many lncRNA molecules are under investigation for their role in tumorigenesis, metastasis, and prognosis in different types of cancer. This review not only summarizes the characteristics and functions of lncRNAs but also discusses the therapeutic implications and applications of lncRNAs with roles associated with head and neck cancer. Our aim is to pinpoint the potential way to perturb specific lncRNAs for future therapeutic use.
Publication Information
Output type
Original language
English (US)Pages from-to (Number of pages)
Pages 107-114 (8 pages)Publication milestones
- Published - 2021
Publication status
Publisher
SpringerPublication series
- Publication series name: Advances in Experimental Medicine and Biology
ISSN (Print): 0065-2598
ISSN (Electronic): 2214-8019
Volume: 1286
Publication IDs
- Scopus: 85102855727
- PubMed: 33725348
- ORCID: /0000-0002-1856-7289/work/93132096