Optical absorbance and optical rotatory dispersion studies on calf thymus nucleohistone
- Dorothy Y.H. Tuan(corresponding author),
- James Bonner
- California Institute of Technology
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Peer-reviewAbstract
Optical absorption and optical rotatory dispersion studies of native nucleohistone and of nucleohistone fully or partially and selectively dissociated into DNA and histone, show that (1) the conformation of whole histone mixtures as well as of individual histone fractions is highly ionic strength dependent and that the conformation of histone in association with DNA approximates that of free histone in solutions of high ionic strength; (2) the conformation of DNA in native nucleohistone is altered as compared to free DNA; and (3) neither lysinerich histone I nor non-histone protein is responsible for the conformational characteristics of DNA in nucleohistone.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Research
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 59-76 (18 pages)Journal (Volume, Issue Number)
Journal of Molecular Biology (Volume 45, Issue 1)Publication milestones
- Published - 10/14/1969
Publication status
Published - 10/14/1969
ISSN
0022-2836Publication IDs
- Scopus: 0014675032
- PubMed: 5387945
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Funding Details
We thank ProfessorN orman Davidson and Dr Roger Chalkley for helpful disoussions and suggeatione. This work was supportedi n part by U. S. Publia Health Service grant CM 13782and the M&&m Fund of the Celifornie Institute of Technology.
FundersFunding number
Celifornie Institute of Technology
-U. S. Publia Health Service
CM 13782and