Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue
- John T. Tomlinson,
- Gyungse Park,
- Jacob A. Misenheimer,
- Gregory L. Kucera,
- Kevin Hesp,
- Richard A. Manderville(corresponding author)
- Wake Forest University,
- University of Guelph
Scholary Output:
Contribution to journal
Article
Peer-reviewSustainable Development Goals
SDG 3 Good Health and Well
Abstract
(Chemical Equation Presented) The prodigiosin alkaloid 1 and the synthetic analogue 2 show photoinduced cytotoxicity against HL-60 cancer cells. Photoirradiation of 1 and 2 causes photofading, photooxidation, and thioadduct formation. These results provide a model for the redox properties of prodigiosins that play a role in their biological activity and provide a new way to functionalize their pyrromethene entity with water-soluble thiol groups.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 4951-4954 (4 pages)Journal (Volume, Issue Number)
Organic Letters (Volume 8, Issue 21)Publication milestones
- Published - 10/12/2006
Publication status
Published - 10/12/2006
ISSN
1523-7060Publication IDs
- Scopus: 33750369211
- PubMed: 17020344
Publication metrics
Metrics
Fractional count
1
Fractional count
0.17
Fractional count
5
Fractional count
0.83
Fractional count
1
Fractional count
1
SciVal
FWCI
0.97
SciVal
Author count
6
SciVal
citations
17
SciVal
Paper percentile
70
PlumX, opens in new tab
Captures
23
Mentions
2
Citation count
20