Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome
- Mark O. Goodarzi,
- Heath J. Antoine,
- Marita Pall,
- Jinrui Cui,
- Xiuqing Guo,
- Ricardo Azziz(corresponding author)
- Cedars-Sinai Medical Center,
- University of California at Los Angeles
Scholary Output:
Contribution to journal
Article
Peer-review
Open access
Abstract
In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3β contributes to the pathophysiology and inherited basis of PCOS.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 1473-1476 (4 pages)Journal (Volume, Issue Number)
Fertility and sterility (Volume 87, Issue 6)Publication milestones
- Published - 06/2007
Publication status
Published - 06/2007
ISSN
0015-0282Publication IDs
- Scopus: 34249729521
- PubMed: 17270183
Publication metrics
Metrics
SciVal
FWCI
1.03
SciVal
Author count
6
SciVal
citations
18
SciVal
Paper percentile
71
Fractional count
1
Fractional count
0.17
Fractional count
5
Fractional count
0.83
Fractional count
1
Fractional count
1
PlumX, opens in new tab
Captures
20
Citation count
21
Funding Details
Supported in part by National Institutes of Health (Bethesda, Maryland) grants R03-HD42077, R01-HD29364, K24-HD01346-01, and M01-RR00425 and by the Helping Hand of Los Angeles (Los Angeles, California).
FundersFunding numbers
NIH
K24-HD01346-01, R03-HD42077, M01-RR00425, R01-HD29364
NICHD
K24HD001346