Rapid hypotensive response to fasting in spontaneously hypertensive rats
- Sharyn M. Fitzgerald(corresponding author),
- John E. Hall,
- University of Mississippi,
- University of Gothenburg,
Open access
Abstract
This study examined changes in renal function and mean arterial pressure (MAP) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats during 48 h of fasting, independent of changes in sodium intake. Spontaneously hypertensive rats (n = 17) and WKY rats (n = 10) were instrumented with artery and vein catheters and sodium intake was clamped at 2.1 mEq/day. By day 2 of fasting, MAP decreased -10 ± 1 mm Hg (P < .001) in SHR, but did not change significantly in WKY rats. Heart rate decreased significantly in both groups by day 2 of fasting and there was a significant increase in urine volume and sodium excretion. Thus, fasting caused a rapid decrease in MAP in SHR that was not due to decreased sodium intake, but may be related, in part, to volume loss and improved renal excretory function.
Publication Information
Output type
Original language
English (US)Pages from-to (Number of pages)
Pages 1123-1127 (5 pages)Journal (Volume, Issue Number)
American journal of hypertension (Volume 14, Issue 11 I)Publication milestones
- Published - 2001
Publication status
ISSN
0895-7061Publication IDs
- Scopus: 0034761241
- PubMed: 11724211