Resident dendritic cell density in the lymph node paracortex is preDC-estined
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- Gwendalyn J. Randolph(corresponding author)
- ,
- ,
- Washington University St. Louis
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Sustainable Development Goals
SDG 3 Good Health and Well
Abstract
Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.
Publication Information
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Scholary Output:
Contribution to journal
Comment/debate
Research
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 1699-1701 (3 pages)Journal (Volume, Issue Number)
Immunity (Volume 56, Issue 8)Publication milestones
- Published - 08/08/2023
Publication status
Published - 08/08/2023
ISSN
1074-7613Publication IDs
- Scopus: 85166676781
- PubMed: 37557075
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Funding Details
The authors declare no competing interests.