Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease
- Mehmet Cansev,
- Ismail H. Ulus,
- ,
- Timothy J. Maher,
- Richard J. Wurtman(corresponding author)
- Uludag University,
- Massachusetts Institute of Technology,
- Massachusetts College of Pharmacy and Health Sciences
Abstract
Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.
Publication Information
Output type
Original language
English (US)Pages from-to (Number of pages)
Pages 206-209 (4 pages)Journal (Volume, Issue Number)
Neuroscience Research (Volume 62, Issue 3)Publication milestones
- Published - 11/2008
Publication status
ISSN
0168-0102Publication IDs
- Scopus: 52949131866
- PubMed: 18761383