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Role of Periodontal Infection, Inflammation and Immunity in Atherosclerosis

  • Harry Choi
    ,
  • Amit K. Dey
    ,
  • Aditi Priyamvara
    ,
  • Milena Aksentijevich
    ,
  • Dhrubajyoti Bandyopadhyay
    ,
  • Debashish Dey
Scholary Output:
Contribution to journal
Article
 Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Background: Inflammation plays a major role in the development and progression of cardiovascular disease (CVD) morbidity and mortality. The well-established relationship between periodontal disease (PD) and CVD may be causal. Left untreated, PD can lead to high systemic inflammation, thus contributing to inflammatory CVD, such as atherosclerosis. Multiple mechanisms have been proposed to elucidate the causal relationship between PD and its contribution to CVD. Objective: This review article highlights the current evidence supporting the role of PD in the development and progression of atherosclerosis. Methods: After creating a list of relevant medical subject heading (MeSH) terms, a systematic search within PubMed in English for each MeSH term between 2000 and 2019 was used to generate evidence for this review article. Conclusion: There is overwhelming evidence in the current literature that supports an association between PD and CVD that is independent of known CVD risk factors. However, the supporting evidence that PD directly causes CVD in humans continues to remain elusive. Multiple biologically plausible mechanisms have been proposed and investigated, yet most studies are limited to mouse models and in vitro cell cultures. Additional studies testing the various proposed mechanisms in longitudinal human studies are required to provide deeper insight into the mechanistic link between these 2 related diseases.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Journal (Volume, Issue Number)

Current Problems in Cardiology (Volume 46, Issue 3)

Publication milestones

  • Published - 03/01/2021

Publication status

Published - 03/01/2021

ISSN

0146-2806

Publication IDs

  • PubMed: 32646544
  • Scopus: 85087477140
  • ORCID: /0000-0003-0253-1174/work/110363106

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