Selective recapitulation of conserved and nonconserved regions of putative noxa1 protein activation domain confers isoform-specific inhibition of nox1 oxidase and attenuation of endothelial cell migration
- Daniel J. Ranayhossaini,
- Andres I. Rodriguez,
- Sanghamitra Sahoo,
- Beibei B. Chen,
- Rama K. Mallampalli,
- Eric E. Kelley
- Vascular Medicine Institute and Departments,
- Pharmacology and Chemical Biology,
- University of Pittsburgh,
- VA Medical Center
Scholary Output:
Contribution to journal
Article
Peer-review
Open access
Abstract
Background: Nox1, an oxidant source in colon carcinoma and vascular disease, is activated by NOXA1. Results: A NOXA1 peptide blocked NOXA1-Nox1 binding and inhibited colon carcinoma and endothelial oxidants and migration. Conclusion: The findings identify a NOXA1-Activating domain and an isoform-specific Nox1 inhibitor. Significance: The data provide insight into Nox1 regulation and present a potential therapy for suppressing oxidative stressrelated disease.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 36437-36450 (14 pages)Journal (Volume, Issue Number)
Journal of Biological Chemistry (Volume 288, Issue 51)Publication milestones
- Published - 12/20/2013
Publication status
Published - 12/20/2013
ISSN
0021-9258Publication IDs
- Scopus: 84890935863
- PubMed: 24187133
Publication metrics
Metrics
SciVal
FWCI
1.12
SciVal
Author count
10
SciVal
citations
51
SciVal
Paper percentile
93
SciVal
Top percentile
10
Fractional count
1
Fractional count
0.10
Fractional count
9
Fractional count
0.90
Fractional count
1
Fractional count
1
PlumX, opens in new tab
Citation count
69
Captures
37
Funding Details
FunderFunding number
NHLBI
R01HL098174