Synchrotron radiation circular dichroism (SRCD) spectroscopy: An emerging method in structural biology for examining protein conformations and protein interactions
- B. A. Wallace(corresponding author),
- Kunihiko Gekko,
- Søren Vrønning Hoffmann,
- Yi Hung Lin,
- ,
- Ye Tao
- Birkbeck University of London,
- Hiroshima University,
- Aarhus University,
- National Synchrotron Radiation Research Center Taiwan,
- East Carolina University,
- Brookhaven National Laboratory
Abstract
Circular dichroism (CD) spectroscopy is a well-established technique in structural biology. The use of synchrotron radiation as an intense light source for these measurements extends the applications possible using lab-based instruments. In recent years, there has been a major growth in synchrotron radiation circular dichroism (SRCD) beamlines worldwide, including ones at the NSLS, ISA, SRS, HiSOR, BSRF, NSRRC, SOLEIL, Diamond, TERAS, BESSYII, and ANKA synchrotrons. Through the coordinated efforts of beamline scientists and users at these sites, important proof-of-principle studies have been done enabling the method to be developed for novel and productive studies on biological systems. This paper describes the characteristics of SRCD beamlines and some of the new types of applications that have been undertaken using these beamlines.
Publication Information
Output type
Original language
English (US)Pages from-to (Number of pages)
Pages 177-178 (2 pages)Journal (Volume, Issue Number)
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment (Volume 649, Issue 1)Publication milestones
- Published - 09/01/2011
Publication status
ISSN
0168-9002Publication IDs
- Scopus: 79961171352