Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes
- Jose L. Gonzalez,
- Chad E. Stephens,
- Tanja Wenzler,
- Reto Brun,
- Farial A. Tanious,
- W. David Wilson
- Georgia State University,
- Swiss Tropical and Public Health Institute,
- Ohio State University
Scholary Output:
Contribution to journal
Article
Peer-reviewAbstract
A series of bis-2,5-[4-guanidinophenyl]thiophenes were prepared in a five step process starting from 2,5-bis[trimethylstannyl]thiophene. The compounds were evaluated in vitro against Trypanosoma brucei rhodesiense (T. b. r.), Plasmodium falciparum (P. f.), Leshmania donovani (L. d.) and Trypanasoma cruzi (T. c.), and in vivo against T. b. r. Certain compounds show promising in vitro activity against T. b. r. and P. f. and have superior in vivo activity against T. b. r. to that of pentamidine and furamidine.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 552-557 (6 pages)Journal (Volume, Issue Number)
European Journal of Medicinal Chemistry (Volume 42, Issue 4)Publication milestones
- Published - 04/2007
Publication status
Published - 04/2007
ISSN
0223-5234Publication IDs
- Scopus: 34047175303
- PubMed: 17178177
Publication metrics
Metrics
Fractional count
1
Fractional count
0.11
Fractional count
8
Fractional count
0.89
Fractional count
1
Fractional count
1
SciVal
citations
52
SciVal
FWCI
1.91
SciVal
Author count
9
SciVal
Paper percentile
89
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Captures
38
Citation count
61
Funding Details
This work was supported by an award from the Bill and Melinda Gates Foundation and NIH grant GM61587. The technical assistance with the in vivo experiments by Guy Riccio (Swiss Tropical Institute) is greatly appreciated.
FundersFunding number
NIH
-NIGMS
R01GM061587
BMGF
-