TEDDY - The Environmental Determinants of Diabetes in the Young: An observational clinical trial
- William A. Hagopian,
- Åke Lernmark(corresponding author),
- Marian J. Rewers,
- Olli G. Simell,
- Jin Xiong She,
- Anette G. Ziegler
- Pacific Northwest Diabetes Research Institute,
- Lund University,
- University of Colorado Denver,
- University of Turku,
- ,
- Institut fur Diabetesforschung
Sustainable Development Goals
SDG 3 Good Health and Well
Abstract
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (6) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.
Publication Information
Output type
Host publication Subtitle
Progress in Our UnderstandingOriginal language
English (US)Pages from-to (Number of pages)
Pages 320-326 (7 pages)Publication milestones
- Published - 10/2006
Publication status
Publisher
Blackwell Publishing Inc.Publication series
- Publication series name: Annals of the New York Academy of Sciences
ISSN (Print): 0077-8923
ISSN (Electronic): 1749-6632
Volume: 1079
ISBN (Print)
1573316415, 9781573316415Publication IDs
- Scopus: 33845701367
- PubMed: 17130573