The effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages
- Warren B. Karp(corresponding author),
- Thomas F. Gale,
- S. B. Subramanyam,
- Robert H. DuRant
- Augusta University,
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Abstract
This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorylase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.
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Scholary Output:
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Article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 351-358 (8 pages)Journal (Volume, Issue Number)
Environmental Research (Volume 36, Issue 2)Publication milestones
- Published - 04/1985
Publication status
Published - 04/1985
ISSN
0013-9351Publication IDs
- Scopus: 0021991735
- PubMed: 2983977
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Funding Details
We thank Ms. Peggy King for her help in preparing the manuscript for publication. This study was supported in part by a grant from the American Heart Association. Georgia Affiliate, and the Department of Pediatrics, Medical College of Georgia.