The expression of smad signaling pathway in myocardium and potential therapeutic effects
- Yuping Duan,
- Wei Zhu(corresponding author),
- Min Liu,
- Muhammad Ashraf,
- Meifeng Xu
- University of Cincinnati,
- Jiangsu University
Scholary Output:
Contribution to journal
Review article
Peer-reviewAbstract
Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.
Publication Information
Output type
Scholary Output:
Contribution to journal
Review article
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 651-659 (9 pages)Journal (Volume, Issue Number)
Histology and Histopathology (Volume 32, Issue 7)Publication milestones
- Published - 07/2017
Publication status
Published - 07/2017
ISSN
0213-3911Publication IDs
- Scopus: 85017258064
- PubMed: 27844469
Publication metrics
Metrics
SciVal
citations
8
SciVal
FWCI
0.54
SciVal
Author count
5
SciVal
Paper percentile
71
Fractional count
1
Fractional count
0.20
Fractional count
4
Fractional count
0.80
Fractional count
1
Fractional count
1
PlumX, opens in new tab
Captures
25
Citation count
17
Funding Details
This work was supported by National Institutes of Health grants HL105176 and HL114654 (Meifeng Xu), National Natural Science Foundation of China (Grant no. 81270214, Wei Zhu).