The p38 and p34 polypeptides of growth cone particle membranes are the α- and β-subunits of G proteins
- Brian T. Edmonds,
- Carolyn R. Moomaw,
- Joan T. Hsu,
- ,
- Leland Ellis(corresponding author)
- University of Texas Southwestern Medical Center
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Peer-reviewAbstract
Growth cone particle (GCP) membranes prepared from fetal day 17 rat brain are comprised of 5 major polypeptides as analyzed by SDS-PAGE: tubulin (p52), actin (p42), pp46/GAP-43 and two unidentified species, p38 and p3414,46,52. Antibodies specific for the α- and β-subunits of G proteins recognize p38 and p34, respectively, on immunoblots following one- and two-dimensional electrophoretic separation. That G protein subunits comprise major species of GCP membrane-associated polypeptides suggests a role for G proteins in transmembrane signaling in nerve growth cones.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Research
Peer-reviewOriginal language
English (US)Pages from-to (Number of pages)
Pages 131-136 (6 pages)Journal (Volume, Issue Number)
Developmental Brain Research (Volume 56, Issue 1)Publication milestones
- Published - 10/01/1990
Publication status
Published - 10/01/1990
ISSN
0165-3806Publication IDs
- Scopus: 0025180464
- PubMed: 2126227
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Funding Details
We wish to thank Suzi Mumby and AI Gilman for generously providing G protein specific antibodies, our colleagues in the Ellis lab for their advice and discussions, Flora Katz for many thoughtful discussions and Flora Katz and AI Gilman for their comments on the manuscript. This work was supported by the Howard Hughes Medical Institute.
FunderFunding numbers
HHMI
-