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The pupillary light reflex as a point-of-care test for suicide risk: Preliminary results

*Corresponding author for this work
Scholary Output:
Contribution to journal
Article
 Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

The pupillary light reflex (PLR) reflects physiologic arousal, and a potential point-of-care biomarker of suicide risk. We collected data from 9 healthy controls, 6 non-suicidal depressed patients, 7 with prior suicide attempts but not presently suicidal, and 8 depressed patients who were actively suicidal. The pupillary maximum constriction velocity (MCV) was similar between the non-suicidal depressed patients and healthy controls (the “Never suicidal” group). Patients with prior attempt resembled the patients expressing active suicidal ideation (the “Ever suicidal” group). MCV was a significant predictor within a logistic regression model of participants who were “Ever suicidal” versus “Never suicidal”.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Article number

113582

Journal (Volume, Issue Number)

Psychiatry Research

Publication milestones

  • Accepted/In press - 2020
  • Published - 11/2020

Publication status

Published - 11/2020

ISSN

0165-1781

Publication IDs

  • ORCID: /0000-0001-5035-7858/work/83712321
  • ORCID: /0000-0001-9919-3380/work/84011022
  • Scopus: 85096598108
  • PubMed: 33234325

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4
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0.80
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0.20
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4
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5
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81
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11
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Funding Details

Dr. Youssef receives research support from MECTA Corp and Merck, the Department of Veteran Affairs and The Augusta Biomedical Research Corporation. Dr. Youssef received Speaker CME honoraria from the Georgia Department of Behavioral Health and Developmental Disabilities (DHBDD) and Psychiatric Annals for unrelated CME topics. In the past 12 months, Dr. Miller received research support from Alkermes, Augusta University, NARSAD, the National Institute of Mental Health, and the Stanley Medical Research Institute; and Honoraria from Psychiatric Times. There was no external funding for this study. It was supported by the Department of Psychiatry and Health Behavior at Medical College of Georgia.