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The role of glutathione in renal cortical tissue. effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity

  • Dennis J. Pillion(corresponding author)
    ,
  • Lamar Moree
    ,
  • Hector Rocha
    ,
  • David H. Pashley
    ,
  • Joseph Mendicino
    ,
  • Frederick H. Leibach
*Corresponding author for this work
  • Medical College of Georgia
    ,
  • Oral Biology
    ,
  • University of Georgia
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 109-115 (7 pages)

Journal (Volume, Issue Number)

Molecular and Cellular Biochemistry (Volume 18, Issue 2-3)

Publication milestones

  • Published - 12/1977

Publication status

Published - 12/1977

ISSN

0300-8177

Publication IDs

  • Scopus: 0017567157
  • PubMed: 146823

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