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Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

  • Thomas N. Seyfried(corresponding author)
    ,
  • Gilbert H. Glaser
    ,
  • Robert K. Yu
*Corresponding author for this work
  • Yale University
Scholary Output:
Contribution to journal
Article
 Peer-review

Abstract

Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enchanced by treatment with excess thyroxine.

Publication Information

Output type

Scholary Output:
Contribution to journal
Article
 Peer-review

Original language

English (US)

Pages from-to (Number of pages)

Pages 598-600 (3 pages)

Journal (Volume, Issue Number)

Science (Volume 205, Issue 4406)

Publication milestones

  • Published - 1979

Publication status

Published - 1979

ISSN

0036-8075

Publication IDs

  • Scopus: 0018388547
  • PubMed: 451624

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59
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