To die, or not to die: E2F1 never decides by itself during serum starvation
- Daitoku Sakamuro(corresponding author),
- Watson P. Folk,
- Alpana Kumari
- ,
- Medical College of Georgia
Scholary Output:
Contribution to journal
Article
Peer-review
Open access
Sustainable Development Goals
SDG 3 Good Health and Well
Abstract
The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.
Publication Information
Output type
Scholary Output:
Contribution to journal
Article
Peer-reviewOriginal language
English (US)Article number
e981447Journal (Volume, Issue Number)
Molecular and Cellular Oncology (Volume 2, Issue 2)Publication milestones
- Published - 04/03/2015
Publication status
Published - 04/03/2015
Publication IDs
- Scopus: 85020154367
Publication metrics
Metrics
Fractional count
1
Fractional count
0.33
Fractional count
2
Fractional count
0.67
Fractional count
1
Fractional count
1
SciVal
citations
2
SciVal
FWCI
0.08
SciVal
Author count
3
SciVal
Paper percentile
40
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Citation count
4
Captures
2
Funding Details
This work was supported in part by the grant from the US National Institutes of Health (NIH) (R01CA140379) (to D.S.).
FunderFunding number
NIH
R01CA140379