Immunology Center of Georgia

2024

Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition

Cai, Y., Zhou, Y., Yang, Q., Xu, J., Da, Q., Ma, Q., Zhao, D., Lu, T., Kim, H. W., Fulton, D., Jiang, X., Weintraub, N. L., Dong, K., Xu, S., Hong, M., Liu, Z. & Huo, Y., Mar 22 2024, (E-pub ahead of print) In: Pharmacological Research. p. 107156

Research output: Contribution to journal › Article › peer-review

2023

A predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years

Bao, B., Zahiri, J., Gazestani, V. H., Lopez, L., Xiao, Y., Kim, R., Wen, T. H., Chiang, A. W. T., Nalabolu, S., Pierce, K., Robasky, K., Wang, T., Hoekzema, K., Eichler, E., Lewis, N. E. & Courchesne, E., Feb 2023, In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells

Kotidis, P., Donini, R., Arnsdorf, J., Hansen, A. H., Voldborg, B. G. R., Chiang, A. W. T., Haslam, S. M., Betenbaugh, M., Val, I. J. D., Lewis, N. E., Krambeck, F. & Kontoravdi, C., Mar 2023, In: Metabolic Engineering.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

GlycoMME, a Markov modeling platform for studying N-glycosylation biosynthesis from glycomics data

Liang, C., Chiang, A. W. T. & Lewis, N. E., Jun 2023, In: STAR Protocols.

Research output: Contribution to journal › Article › peer-review

Preparing glycomics data for robust statistical analysis with GlyCompareCT

Zhang, Y., Krishnan, S., Bao, B., Chiang, A. W. T., Sorrentino, J. T., Schinn, S-M., Kellman, B. P. & Lewis, N. E., Jun 2023, In: STAR Protocols.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

T-Cell Clonality, Functional Changes, and Clinical Response after Dupilumab in Atopic Dermatitis and Asthma Patients

Dilley, M., Loop, L., Croker, B., Aceves, S., Lewis, N., Zhu, Y., Lee, J., Shamie, I., Chiang, A., Tambay, A. & Geng, B., Feb 2023, In: Journal of Allergy and Clinical Immunology.

Research output: Contribution to journal › Article › peer-review

2022

Artificial intelligence in the analysis of glycosylation data

Li, H., Chiang, A. W. T. & Lewis, N. E., Nov 2022, In: Biotechnology Advances.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration

Kellman, B. P., Richelle, A., Yang, J-Y., Chapla, D., Chiang, A. W. T., Najera, J. A., Liang, C., Fürst, A., Bao, B., Koga, N., Mohammad, M., Bruntse, A. B., Haymond, M. W., Moremen, K., Bode, L. & Lewis, N. E., May 4 2022, In: Nature communications.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Esophageal Fibroblasts are the Players in the Interferon Response in Eosinophilic Esophagitis

Wu, A., Nhu, Q., Chiang, A., Manresa, M., Kurten, R., Lewis, N. & Aceves, S., Feb 2022, In: Journal of Allergy and Clinical Immunology.

Research output: Contribution to journal › Article › peer-review

LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms

Manresa, M. C., Wu, A., Nhu, Q. M., Chiang, A. W. T., Okamoto, K., Miki, H., Kurten, R., Pham, E., Duong, L. D., Lewis, N. E., Akuthota, P., Croft, M. & Aceves, S. S., Feb 2022, In: Mucosal Immunology.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine

Tsai, C-M., Caldera, J. R., Hajam, I. A., Chiang, A. W. T., Tsai, C-H., Li, H., Díez, M. L., Gonzalez, C., Trieu, D., Martins, G. A., Underhill, D. M., Arditi, M., Lewis, N. E. & Liu, G. Y., Aug 2022, In: Cell Host and Microbe.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

S100A4 Levels in Pediatric Eosinophilic Esophagitis Cohort

Babbel, J., Dong, S., Lewis, N., Mo, J., Faulkner, C., Chiang, A., Hsieh, L., Aceves, S. & Kurten, R., Feb 2022, In: Journal of Allergy and Clinical Immunology.

Research output: Contribution to journal › Article › peer-review

2021

A Unique Esophageal Extracellular Matrix Proteome Alters Normal Fibroblast Function in Severe Eosinophilic Esophagitis.

Chiang, A., Feb 5 2021, In: The Journal of Allergy and Clinical Immunology.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis

Bao, B., Kellman, B., Chiang, A. W. T., Zhang, Y., Sorrentino, J., York, A. K., Mohammad, M., Haymond, M. W., Bode, L. & Lewis, N. E., Aug 17 2021, In: Nature communications.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Dysregulation of the secretory pathway connects Alzheimer’s disease genetics to aggregate formation

Chiang, A., Jun 2021, In: Cell Systems.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Genome wide analysis of heparan sulfate assembly

Esko, J., Weiss, R., Spahn, P., Chiang, A., Liu, Q., Li, J., Hamill, K., Rother, S., Clausen, T., Hoeksema, M., Timm, B., Godula, K., Glass, C., Tor, Y., Gordts, P. & Lewis, N., May 2021, In: FASEB Journal.

Research output: Contribution to journal › Article › peer-review

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.

Chiang, A., Apr 12 2021, In: Nature Chemical Biology.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Model-based assessment of mammalian cell metabolic functionalities using omics data

Chiang, A., Jun 2021, In: Cell Reports Methods.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy

Chiang, A., Dec 2021, In: Journal of Biomedical Science.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The human milk oligosaccharide 3’sialyllactose promotes inflammation resolution and reduces atherosclerosis development.

Pessentheiner, A., Spann, N., Collins, C., Ramms, B., Chiang, A., Wang, Y., Quach, A., Booshehri, L., Hammond, A., Tognaccini, C., Latasiewicz, J., Witztum, J. L., Hoffman, H., Lewis, N., Glass, C., Bode, L. & Gordts, P., Aug 2021, In: Atherosclerosis.

Research output: Contribution to journal › Article › peer-review

Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders

Chiang, A., May 1 2021, In: Journal of Pediatric Gastroenterology and Nutrition. 72, 5, p. 718-722 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2020

A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR)

Kellman, B. P., Zhang, Y., Logomasini, E., Meinhardt, E., Chiang, A. W. T., Sorrentino, J. T., Liang, C., Bao, B., Zhou, Y., Akase, S., Sogabe, I., Kouka, T., Wilson, I. B. H., Campbell, M. P., Neelamegham, S., Krambeck, F. J., Aoki-Kinoshita, K. F. & Lewis, N. E., 2020, In: Beilstein Journal of Organic Chemistry.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Chiang, A., Nov 2020, In: Current Research in Biotechnology.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Elucidate Glycosyltransferase Specificities And Interactions for Rational Glycoengineering

Liang, C., Chiang, A. W. T., Hansen, A. H., Arnsdorf, J., Schoffelen, S., Sorrentino, J. T., Kellman, B. P., Bao, B., Voldborg, B. G. & Lewis, N. E., Apr 2020, In: FASEB Journal.

Research output: Contribution to journal › Article › peer-review

Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype

Chiang, A., Nov 2020, In: Gastroenterology.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Multiplex secretome engineering enhances recombinant protein production and purity

Kol, S., Ley, D., Wulff, T., Decker, M., Arnsdorf, J., Gutierrez, JM., Chiang, AW., Pedersen, LE., Kildegaard, HF., Lee, GM. & Lewis, NE., 2020, In: Nature communications.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis

Weiss, R. J., Spahn, P. N., Toledo, A. G., Chiang, A. W. T., Kellman, B. P., Li, J., Benner, C., Glass, C. K., Gordts, P. L. S. M., Lewis, N. E. & Esko, J. D., 2020, In: Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2019

Combating viral contaminants in CHO cells by engineering innate immunity

Chiang, A. W. T., Li, S., Kellman, B. P., Chattopadhyay, G., Zhang, Y., Kuo, C-C., Gutierrez, J. M., Ghazi, F., Schmeisser, H., Ménard, P., Bjørn, S. P., Voldborg, B. G., Rosenberg, A. S., Puig, M. & Lewis, N. E., 2019, In: Scientific reports.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations